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BDNF and proBDNF appear to be linked to craving and relapse risk in early withdrawal periods, but the persistence of higher levels over several months reveals a deeper and more complex disruption of neurotrophin production, reflecting enduring and long-term reactive structural and functional changes in neurotrophic equilibrium

They can cause the amino acid bonds to break down (a process called hydrolysis) or the entire molecule to change shape, rendering it biologically inert

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