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Insulin-like growth factor (IGF), prolactin, sex hormone-binding globulin (SHBG), DHEA (dehydroepiandrosterone), testosterone, and thyroid hormones must also be optimized

These adaptations reflect neuroplastic remodeling of pain circuits rather than restoration of tissue integrity

Krivic et al., 2008) or ligament ( In this issue, the already mentioned Tkalcevic and collaborators study may be illustrative (Seveljevic-Jaran et al., 2006