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JNK are a family of protein kinases that play a central role in stress signaling pathways associated with gene expression, neuronal plasticity, regeneration, cell death, and regulation of cell aging

Its clinical application as an antibacterial agent, however, was hampered by the development of allergic reactions (red-man syndrome), bone marrow suppression, vestibular and renal toxicity

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Ann Allergy Asthma Immunol 122:263269 Nakatsuji T, Hata TR, Tong Y, Cheng JY, Shafiq F, Butcher AM, Salem SS, Brinton SL, Rudman Spergel AK, Johnson K (2021) Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial