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[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Alfaris N., Alqahtani A.M., Alamuddin N., Rigas G

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Although the retro-inverso approach may fail to accurately reproduce biological function in the context of helical structures (e.g., p53 or HIV-1 proteins), certain exceptionssuch as the binding of a p53-derived retro-inverso peptide to its regulator MDM2demonstrate that well-designed D-peptides can, in specific cases, effectively mimic the function of the original peptide

In preclinical rat studies, our biochemical plumber has been shown to lay down new pipes by inducing angiogenesisthe formation of new blood vessels that carry vital nutrients and remove waste (Sikiric et al