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But, this therapy has some side effects for men, including carpal tunnel syndrome (CTS), increased resistance to insulin, swelling in the arms and legs (edema), muscle and joint pain, and enlargement of breast tissue

As tirzepatide levels decrease, these medications may need dose adjustments to prevent low blood sugar

QA accumulation is associated with brain inflammation and cell death, and patients with advanced CKD exhibit elevated plasma KYN metabolites and QA, which uniquely correlate with fatigue and reduced quality of life (Saliba et al., 2024), supporting the role of gut-derived KYN metabolites in linking CKD to neuroinflammation

The aforementioned impaired ability to neutralize ROS may also increase the risk of reperfusion injury in this patient population