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BPC-157 evidence base is concentrated in a single research group (Sikiric and collaborators at the University of Zagreb), with limited fully independent replication

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For example, the administration of the insulin growth factor small-interfering RNA blocks KET antidepressant effects in the mouse learned helplessness model of depression (Grieco et al., 2016)

KPV demonstrates potent anti-inflammatory effects through cytokine modulation