It was engineered to improve receptor selectivity, reduce immunogenicity risk, and improve pharmaceutical developability
Pharmacological studies have shown that metabolites produced by traditional botanical drugs can promote OBs, inhibit OCs, and regulate estrogen levels, as well as promote osteogenesis, inhibit adipogenesis in bone marrow mesenchymal stem cells (BMSCs), regulate calcium and phosphorus metabolism, and inhibit oxidative stress (OS) (Duan et al., 2023)
In some embodiments, the formulation or composition comprises between about 0.01% to about 80% by weight of the viscosity modulating agent
By inhibiting this interaction, FOXO4-DRI allows reactivation of the apoptotic pathway in non-proliferative senescent cells, leading to their selective elimination without damaging healthy tissue