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Lancet Oncol 19: e430, 2018

Sci Rep 6(1):21200

The combination of GLP-1 medication with reduced food intake creates a perfect storm for B-vitamin depletion

K48-linked ubiquitination promotes proteasomal degradation, whereas K63-linked ubiquitination activates NLRP3 by recruiting binding partners, and deubiquitination by enzymes such as BRCA1/BRCA2-containing complex subunit 3 (BRCC3) and ubiquitin-specific protease 1 USP1/UAF1 or BRCC3 reverses this inhibition