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Vitamin B12 combines with and globulin in the blood to be transported to various tissues throughout the body, most of which are distributed in the liver

On the other hand, MAT1 directly interacts with CYP2E1 to promote the methylation of CYP2E1 at R379 site and degradation through the proteasome pathway

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In addition, a large amount of mtDNA is released during the formation of NETs, which acts on HCC cells to activate the cGAS-ncNF-B signaling pathway and induce the invasion of HCC cells [177]