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It suppresses excessive reactive oxygen species (ROS) and maintains mitochondrial function by modulating the Receptor-Interacting Protein Kinase 3-Mixed Lineage Kinase Domain-Like protein (RIP3-MLKL) (necroptosis-related) and Receptor-Interacting Protein Kinase 1 (RIP1)-Nuclear-related factor 2 (Nrf2)-Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-B) (antioxidant/inflammatory) pathways, ultimately promoting cellular survival

This study was undertaken to examine changes and effects of citicoline on phospholipids and glutathione synthesis after transient cerebral ischemia and reperfusion

Statements Author contributions GZ: Writing original draft, Methodology, Supervision, Conceptualization, Writing review & editing

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