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14 It also acts as an anti-proliferative agent and indices apoptosis by a) changing the mitochondrial membrane barrier, b) increasing reactive oxygen species, c) decreasing internal glutathione level , 76,77 d) increasing cytochrome-C activity, e) disturbing B-cell lymphoma-2 and B-cell lymphoma-2-associated X protein (Bcl/Bax) proportion, f) increasing caspase 3 and caspase 9 action, and g) poly ADP ribose polymerase

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