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However, despite low plasma concentrations, pharmacokinetic studies show that berberine has a high tissue distribution rate, accumulating effectively in the liver, kidneys, muscle, and heart where it exerts its metabolic effects

Cell organelle-specific fluorescent probes Mito Tracker Green, Lyso tracker blue, ER tracker green and Golgi tracker green were obtained from Thermo Fischer Scientific, USA

J Pers Med 12:1 Scafidi S, Fiskum G, Lindauer SL, Bamford P, Shi D, Hopkins I, McKenna MC (2010) Metabolism of acetyl-l-carnitine for energy and neurotransmitter synthesis in the immature rat brain