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Given the knowledge gaps in understanding the etiology of neurodegenerative disease, emerging research in microbe-dependent modulation of the ENS and the microbe-ENS-brain axis provides clues into the emergence of enteric dysfunction and neurodegenerative diseases

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Natesto is a nasal administered exogenous 4.5% testosterone gel, administered from a non-pressurized, manual pump dispenser with a specialized nasal applicator which administers 125 uL (5.5mg of testosterone)