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Stem cell factor and its receptor (c-Kit) also play a role in melanogenesis during the hair growth phase

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CHE induced KG1a cells to be sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which activated caspase-8 and downregulated FLIP long and short (Platzbecker et al., 2003)

Among the studies reviewed, L-02 cells have been frequently utilized to study hepatotoxicity mechanisms due to their excellent proliferative capacity and ability to perform typical liver cell functions ( HepaRG cell line is the second most used cellular model and is generally considered as a good surrogate for PHHs when investigating liver metabolism and detoxification ( in vivo situation ( in vitro cholestatic research ( Despite HepG2 and Huh-7 display low biotransformation capacities, they both have been used [Huh-7 ( in vitro models for hepatic toxicity metabolomic studies, because of their stability