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Although the clinical effect of l-asparaginase clearly indicates that asparagine is crucial for tumor survival and metastasis 52 , the importance of asparagine beyond protein synthesis and the mechanism by which asparagine supplementation enhances glutamine-associated metabolism are less well understood

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Some patients may experience: Mild injection site reactions (redness, slight swelling) Temporary drowsiness (related to increased melatonin production) Mild headache in the first few days Serious adverse effects are rare in published literature