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D., Stenson, W

Although Exos have entered clinical trials and shown beneficial effects in various diseases [235], trials specifically investigating MSC-Exos for ferroptosis remain limited in the literature and registered clinical trials

Cytochrome c oxidase subunit 7A1 (COX7A1) exhibits a distinct dual role: It enhances mitochondrial metabolism to sensitize NSCLC cells to cysteine deprivation-induced ferroptosis, while concurrently inhibiting autophagy to block mitochondrial remodeling, two seemingly opposing effects