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As emphasized by Zhao et al., the prolonged progression of AD before clinical symptoms emerge indicates that astrocytes may substantially contribute to disease pathogenesis at a single-cell resolution 12

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MRS Measurements of the GABA/Glx Ratio The imbalance between excitatory neurotransmitters (Glx) and inhibitory neurotransmitters (GABA) is important in the pathogenesis of ALS and a range of other psychiatric and neurological disorders (77)