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This study shows a significant positive correlation between 25(OH)VD and GSH status in adolescents

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Busulfan has a narrow therapeutic index with improved rates of engraftment and lower drug-related toxicity associated with a cumulative area under the curve (cAUC) of approximately 75100 mg*h/L ( Historically, wide-spread clinical practice for busulfan dosing has followed the FDA-approved drug label, with an initial busulfan dose estimation based on actual body weight ( More recently, numerous PK studies have demonstrated population PK models where busulfan clearance (CL) parameter incorporates patient covariates such as body size and age provide improved clinical target attainment when compared to weight-based regimens alone (www.insight-rx.com) for the routine clinical dosing of busulfan and TDM