Abbreviations NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells STAT3: Signal transducer and activator of transcription 3 c-MET: Mesenchymal epithelial transition factor (MET) or hepatocyte growth factor receptor (HGFR) EpCAM: Epithelial cell adhesion molecule COX2: Cyclooxygenase-2 MMP9: Matrix metallopeptidase 9 IKK: IB kinase PI3K: Phosphoinositide 3-kinase AKT: Protein kinase B or (PKB) ERK: Extracellular signal-regulated kinase MAPK: Mitogen-activated protein kinase EGFR: Epidermal growth factor receptor tyrosine kinase EMT: Epithelialmesenchymal transition BCL2: B-cell lymphoma 2 BCLxL: B-cell lymphoma-extra large XIAP: X-linked inhibitor of apoptosis protein ER: Estrogen receptor PR: Progesterone receptor IGFIR: Insulin-like growth factor VEGFR: Vascular endothelial growth factor receptor c-Myc: Myelocytomatosis IKB: Inhibitor of kB References Papaccio F, Della Corte CM, Viscardi G, Di Liello R, Esposito G, Sparano F, et al
doi: 10.1097/FTD.0b013e3181817428 Summary Keywords busulfan, pharmacokinetics, pediatric, therapeutic drug monitoring, hematopoietic cell transplantation Citation Shukla P, Goswami S, Keizer RJ, Winger BA, Kharbanda S, Dvorak CC and Long-Boyle J (2020) Assessment of a Model-Informed Precision Dosing Platform Use in Routine Clinical Care for Personalized Busulfan Therapy in the Pediatric Hematopoietic Cell Transplantation (HCT) Population
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FIGURE 6 In animal models developing T2D, a drastic decrease in cardiolipin levels in striated muscle was identified (Han et al., 2007)
