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The reported lasting relief of symptoms is thought to be due in part to the re-establishment of Meibomian gland orifices and central ducts after the removal of debris and obstructions

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Strategies to minimize reactions include rotating injection sites consistently to avoid repeated trauma to the same area, ensuring the solution is at room temperature before injection (cold injections can increase irritation), injecting slowly rather than quickly, and using a smaller gauge needle for less tissue trauma