Standard dosage: 200400 mg silymarin daily, divided into 23 doses Ideally taken before meals For liver stress: up to 420 mg silymarin daily may be appropriate only after medical consultation Alcohol should be avoided during intake Milk thistle preparations during pregnancy and breastfeeding should only be taken on the explicit recommendation of a doctor or midwife
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Glutathione Depletion: A Modern Epidemic Glutathione levels decline with age - typically by 1015% per decade after age 20 - and are further depleted by: *Chronic illness and autoimmune conditions *Environmental toxin exposure (heavy metals, pesticides) *Poor nutrition (insufficient cysteine, glycine, glutamate precursors) *Chronic psychological stress *Alcohol consumption *Certain medications (acetaminophen, chemotherapy agents) *Intense physical exercise without adequate recovery Given that thyroid disease prevalence increases with age and is associated with chronic immune activation, the parallel decline in glutathione levels is not coincidental - it is mechanistically significant
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