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Recently, investigations indicated that protegrin-derived SynB1 CPPs, and Antennapedia homeodomain-derived penetratin (antp), could increase the doxorubicin delivery (an anticancer drug) across the BBB, which indicates their ability to treat glioblastoma [110, 111]

Its mechanism is competitive inhibition within the NNMT catalytic pocket, blocking the methyl transfer from SAM to nicotinamide

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