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Description

Pharmacological inhibition of cyclophilin D using cyclosporine A provided only temporary protection in vitro66, but cyclophilin D-deficient mice were protected against liver injury when treated with a moderate APAP overdose of 200 mg/kg68

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While this area of research has undoubtedly progressed, it is still not completely clear which biochemical mechanisms are involved

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doi: 10.1016/j.jhepr.2025.101394 57 WuQGeZLvCHeQ

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Pollard, J.D., Quan, S., Kang, T., & Koch, R.J

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