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214 Therefore, to achieve large-scale clinical application, NADs must ensure easy production, quality control, and transportation

While this unidirectional behavior effectively destroys cell metabolism for tumor suppression, it poses challenges because of the absence of coupling between the intracellular nanostructures and endogenous feedback mechanisms, thereby hindering their translation to scenarios requiring sustained cellular viability and precise, nondestructive function modulation, including probiotic interventions 46 , programmable cell-based therapeutics 47 and engineered living materials 48

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Influence of induction chemotherapy and class of cytotoxics on pathologic response and survival after preoperative chemoradiation in patients with carcinoma of the esophagus