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In some cases, severe DILI can progress to acute liver failure or develop into chronic liver disease [59]

During Type 2 immunity, the upregulation of airway epithelial 15-lipoxygenase-1 (15LO1) partners with phosphatidylethanolamine binding protein 1 (PEBP1), forming a complex that shifts substrate specificity toward membrane phospholipids to catalyze pro-ferroptotic 15-HpETE-PE synthesis, a metabolite normally reduced by glutathione peroxidase 4 (GPX4) to its inert alcohol form (10)

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