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A double-blind randomized controlled trial testing an antioxidant combination treatment (vitamin E, vitamin C, and -lipoic acid) in Alzheimers disease patients reported that this treatment was associated with accelerated cognitive decline as measured by the MMSE, despite a decrease in the level of oxidative stress (F2-isoprostane) in the cerebral spinal fluid (CSF) (19)

(1998) the gold-standard comparison A 12-week randomized trial enrolled 67 women with moderate-to-severe facial aging and compared four topical formulations: a copper peptide cream, a vitamin C cream, a melatonin cream, and tretinoin

Fu C, Chen J, Lu J, Yi L, Tong X, Kang L

felineus infection) (23)