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IL-1 is a well-established upstream regulator of age-associated inflammation and induces downstream cytokines including IL-6 and TNF 4,49

YAP can mediate pressure overload-related adaptive cardiac hypertrophy (Byun et al., 2019), and exposure to oxidative stress can promote the phosphorylation of YAP, contributing to the exacerbation of myocardial ischemia/reperfusion injury (Matsuda et al., 2016)

doi: 10.1111/jpn.13385 29 FarjoKMFarjoRAHalseySMoiseyevGMaJ-x

Protective effects of pyrroloquinoline quinine against oxidative stress-induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway