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they may encourage monotherapy for simplicity at the cost of efficacy which may rely on combined or synergistic effects
Several other modulators have been found to promote neurogenesis, reduce the size of infarcts and promote neurological recovery in the brain after HIBD, as follows: Vascular endothelial growth factor (VEGF) binds to the VEGFR2 receptor and activates the Rho/Rok pathway, promoting synaptic growth and playing a crucial role in neuroprotection and neurogenesis ( via the BDNF-TrkB-CREB signaling pathway ( Therapeutic measures for neonatal HIBD to promote endogenous neurogenesis The ability of spontaneous endogenous neurogenesis after neonatal HIBD to repair damaged neurological functions is markedly limited
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