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Van Haren R, Mehran R, Correa A, Antonoff M, Baker C, Hofstetter W, Mena G, Roth J, Sepesi B, Swisher SG , Vaporciyan A, Walsh G, Rice D

Pathological fatigue may be partially alleviated, but never eliminated, by physical, intellectual and emotional rest and/or sleep (non-restorative sleep)

In the decades since, researchers have repeatedly returned to it as an open question in neurochemistry, with one influential review aptly describing it as a "still unresolved riddle" (Kovalzon et al., 2006)