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BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca 2+ -dependent mPTP opening

Retatrutide has produced weight loss results that far exceed those of semaglutide (Ozempic), reducing weight by up to 24% in 48 weeks, compared to semaglutides 17.4% reduction after 68 weeks

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In another phase 2 trial of obese patients with type 2 diabetes, the combination of cagrilintide 2.4 mg/week and the GLP-1R semaglutide 2.4 mg/week (referred to as CagriSema) was compared with each drug alone