(88) in an 8-week randomized double-blind, placebo-controlled trial with 80 individuals experiencing episodic migraines, discovered that the combination of omega-3 PUFAs and nano-curcumin significantly reduced migraine attack frequency and serum levels of IL-1 in a synergistic manner, though the initial significant reduction in IL-1 gene expression did not remain significant after Bonferroni corrections
Among the 55 metabolites identified, the authors have found five potential biomarkers of IBS-D to distinguish from healthy controls: cadaverine, putrescine, threonine, tryptophan, and phenylalanine (78)
A., Antoniuk-Shcheglova, I
Moreover, in rats, supplementation with either phlorotannins, xanthohumol or quercetin (Week (W) 8-16), reversed POS-induced depressive like behavior in the FST at W12-13 [57]