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10.1371/journal.pone.0034854 PLoS One 55 DaskalovA.SaupeS

Likewise, remarkable safety (i.e., LD50 higher than 2000 mg/kg through oral or intravenous route in mice) confirmed no adverse effect in toxicology studies (none of the animals died)

An investigation into a proprietary Vitamin B12 preparation derived from Streptomyces griseus fermentation liquors found that side effects warranted further inquiry to determine the exact cause