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(6) Control : Control group mice should be injected with an equal amount of the corn oil solution of Tamoxifen (using Tamoxifen in a genetic background without Cre recombinase) to rule out the influence of Tamoxifen itself

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21 The characteristics of each study and the patients included in each study (country, design, sample size, age, dose, treatment, intervention, and outcomes) are provided in Table 1