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"MOTS-c levels in human blood decline with age and correlate with insulin sensitivity, positioning the peptide not just as a metabolic tool but as a potential biomarker of mitochondrial vitality." On the exercise side, a pivotal finding came from studies measuring endogenous MOTS-c in human subjects

Phosphorylated transcription factors may enter the nucleus and potentially modulate the transcription of specific genes that have been associated with growth hormone synthesis and secretion