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In the ACTION trial, active surveillance involved the review, by the Data Safety Monitoring Committee, of the total number of patients screened for eligibility, who was eligible, asked for consent, and included plus response rates per study arm and per tumour type, the primary outcome measure and hospital admission and death data in both arms of the trial

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Why that selectivity exists at the receptor level isnt entirely settled it may reflect biased agonism, where the specific binding geometry favors the somatotroph signaling pathway over the corticotroph one, even though both cell populations express GHSR-1a

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