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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )
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Surface modifications of NPs not only affect their pharmacokinetics and change their biodistribution, clearance, and elimination, which are closely related to their toxicity in the body (Yu et al., 2018a)
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