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It is the most physically restorative sleep phase: during delta sleep, growth hormone secretion peaks (~70% of daily secretion), tissue repair processes are maximized, and immune cytokine production is elevated

For instance, studies have demonstrated that gut microbes, such as Desulfovibrionales, can influence the formation of cholesterol-type gallstones by regulating bile acid production and cholesterol secretion (Hu et al., 2022)

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Vascular pathology in multiple sclerosis: reframing pathogenesis around the blood-brain barrier