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However, off-target effects still cause the risk of normal cell damage and serious side effects

Considering the antioxidant effects of regular physical activity (PGC-1, PPAR) and creatine (maintaining mitochondrial integrity, acting as a cellular energy buffer, reducing extracellular H 2 O 2 levels, cell membrane stabilization and improvement of cellular energy capacity), it seems that the combined effect of physical activity and creatine consumption can reduce oxidative stress, but further research is needed to conclude more accurately about the intensity of long-term resistance and endurance training with creatine supplementation and the short-term effects of creatine consumption and physical activity on oxidative stress

See Mitochondrial Peptides: The Next Frontier in Longevity for detailed coverage

Factors affecting the quantification of short echo in vivo 1H MR spectra: prior knowledge, peak elimination, and filtering