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Results Validation of Transfection of GSTP1 in HepG2 Cells To evaluate the role of GSTP1 in protecting against QIs-induced cellular perturbations, HepG2 cells were transiently transfected with a DNA construct containing the human GSTP1 cDNA behind a CMV-promoter

Nitisinone is a modification of mesotrione, a herbicide based on the natural product leptospermone has been used successfully as a treatment of hereditary tyrosinaemia type 1 (HT-1), a severe inherited disease of humans caused by a deficiency of fumarylacetoacetate hydrolase (FAH), leading to accumulation of fumaryl and maleylacetoacetate and progressive liver and kidney damage 125

By helping maintain cellular integrity and mitochondrial efficiency, it may also promote energy production and healthy aging

In conclusion, most of the studies referenced above provided adequate information to formulate summaries, although some text descriptions were rather vague in the methodology used