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162 During breast cancer chemotherapy, specific tumor cells exhibit upregulation of SASP genes, accompanied by an augmented expression of immunosuppressive molecules PD-L1 and CD80 within these tumor cells

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By disrupting the FOXO4-p53 interaction, FOXO4-DRI, a specific FOXO4 blocker, selectively induced p53 nuclear exclusion and apoptosis in senescent Leydig cells