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Introduction Schistosomiasis is recognized as the second most prevalent among the group of NTDs in sub-Saharan Africa, following hookworm infection ( Schistosoma , that results in chronic and acute disease ( Schistosoma are Schistosoma mansoni , Schistosoma haematobium , Schistosoma japonicum , Schistosoma intercalatum , and Schistosoma mekongi ( Schistosomiasis affects the worlds poorest countries where there is no safe water, basic sanitation and hygiene education ( The parasitizing of this infectious disease results in fever, malaise, abdominal pain, and skin rashes in an acute state, while intestinal, liver, urinary tract and lung diseases are the result of chronic infection

and the breakdown of nano drugs by proteases generated in the body [37]