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GSH is a cofactor and a synthetic substrate for GPX4, and it is required for the lipid repair function of GPX4 (Stockwell et al., 2017) and cystine/glutamate reverse transport system Xc- [or xCT/12 channel transmembrane protein transport protein carrier family 7 member 11 (SLC7A11) mediates the uptake of cystine to exchange the output of glutamate] was identified as the pivotal regulator for GSH synthesis (Hao et al., 2018)

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