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Case report A 48-year-old Caucasian female presented with a several-year history of facial melasma, localised symmetrically on the forehead and cheeks, managed by different approaches: chemical peelings, lasers and light treatments and topical treatments, like hydroquinone and other cosmetics with partial and transitional improvement (Figure 1)

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The truncation dramatically reduces binding to IGF binding proteins (IGFBPs), increases receptor affinity, and shortens half-lifecreating a potent, rapidly-acting growth factor with predominantly local rather than systemic effects when administered