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Cells were characterized as previously described ( In vitro differentiation of iPSCs into hepatic cells Human iPSCs were differentiated into HLCs using a growth factor (GF)-based and small molecule-based protocol

Cosmetic outcomes reported for topical use Pickart and Margolinas reviews summarize controlled cosmetic studies in which topical GHK-Cu formulations were reported to tighten loose skin, improve elasticity, increase skin density and firmness, reduce fine lines and wrinkles, reduce photodamage, and reduce hyperpigmentation, alongside increased keratinocyte proliferation

In areas of skin that are not exposed to sunlight, melanocytes decrease with age