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Subsequently, the transcription factor NGN2 (originally provided by laboratories at Stanford University, CA, USA) was introduced under the control of a doxycycline-inducible rtTA element via CRISPR/Cas9-mediated genome engineering into the AAVS1 safe harbor locus

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Sepsis is a systemic inflammatory response caused by excessive cytokine secretion, such as interleukin (IL)-6, IL-10, IL1 and TNF-