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Option (Evidence Strength: Grade C) One randomized trial with an oral PPS group for comparison reported that CyA (3 mg/ kg/day divided into two doses) resulted in 75% of patients experiencing clinically significant improvement compared to 19% of a PPS comparison group after six months of treatment

The structure of MTX consists of a pteridine-diamine core and a p-amino benzoyl portion connected to a glutamic acid segment containing two highly ionizable carboxylic acid groups

Such findings suggest a possible role in maintaining circulation during tissue damage