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For researchers investigating chronic low-grade inflammation (often called inflammaging), it offers a well-characterized tool compound for studying simultaneous antioxidant and anti-inflammatory responses without the systemic suppression that comes from corticosteroids or broad NSAIDs

Common Side Effects Unknown human profile: Because human trials were never completed, adverse-event rates, immunogenicity and long-term risks for either peptide are simply uncharacterised

Mitra Ghosh, T., Mazumder, S., Davis, J., Yadav, J., Akinpelu, A., Alnaim, A., et al

DKK-1 induces LRP5/6 endocytosis in cardiomyocytes, causing GPCR signalling disorder and promoting ischaemia-induced DNA damage in cardiomyocytes