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Reconstituted : May be damaged Visual inspection for crystals If looks clear, might still work but potency uncertain Consider reconstituting fresh vial Left in hot car Powder : Hours: Probably fine Days: Likely degraded Visual inspection won't help Effectiveness test only way to know Reconstituted : Likely degraded significantly Discard and reconstitute fresh Dropped and shattered Safety first : Clean up carefully, glass hazard

Bidwell LC et al (2010): Alpha-2 Adrenergic Receptors and Attention-Deficit/Hyperactivity Disorder

NHLBI 2011a

The 177191 fragment was identified as the lipolytic active site, and a tyrosine residue was added at the N-terminus to enhance stability