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383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)

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By supporting the bodys repair mechanisms including tissue regeneration and regulation of inflammatory pathways, peptides may offer more sustained relief over time compared to medications that only interrupt pain signaling

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