How are peptides for vascular research administered and dosed
In 2011, for example, researchers who administered 1,000mg per day of non-liposomal glutathione found "no significant changes were observed in biomarkers of oxidative stress" in participants after four weeks.2 In contrast, a 2019 study of identical length administered liposomal glutathione at 500-1,000mg doses and saw significant decreases in oxidative stress biomarkers plus improvements in immune system markers.3 Two of our top recommended glutathione supplements are liposomal, by the way: Codeage Liposomal Glutathione, our recommendation for most people Quicksilver Scientific Glutathione, our top liquid glutathione supplement Branded glutathione Glutathione supplements often use one of two branded versions of glutathione that are formulated to improve absorption: Setria or Opitac
Topical Administration (Most Common) The most widely used approach is topical application via DMSO (dimethyl sulfoxide): Dissolve 3-5mg Dihexa in a few drops of DMSO Apply to forearm skin (DMSO acts as a carrier to drive the peptide through the skin) DMSO concentration: ~20-30% in the solution Pros: Effective absorption, avoids injection Cons: DMSO has a strong garlic-like odor that can transfer to breath/skin Starting Dose Begin at 1-3mg topically to assess response Work up to 3-5mg if tolerating well Cycling Protocol Dihexa appears to have lasting effects that persist after stopping likely due to synaptogenesis (new connections don't disappear when you stop)
Alfonso JH, Bauer A, Bensefa-Colas L, et al
